Tumor Susceptibility Gene 101 (TSG101) plays a part in the cell's usual controls on growth or repair, a process that helps cells clear excess proteins. Cleaning ht cell from these excess proteins is called autophagy, and it keeps neuron cells healthy. Rapamycin is a chemical that triggers autophagy. The study showed that Rapamycin increased TSG101 protein level to…

When it comes to living a longer, healthier life, most people think of regular exercise and a balanced diet. These are time-tested ways to boost longevity. But recently, some have turned to prescription drugs like rapamycin, hoping it could help slow aging and extend their lifespan. So, what is rapamycin, and is it really the…

Fixing Forgetfulness: New Clue to Fighting AD? This study involved Assistant Professor Ai-Ling Lin from UT Health San Antonio. Other researchers from the Imaging Research Institute and the Barshop Institute for Aging and Longevity Studies also participated. The aim was to see how rapamycin can help mice with induced Alzheimer's disease. There were three critical…

Special Medicine for Kidneys with Polycystic Disease This study looks at how well the RapaMNP medicine works in treating kidneys with polycystic disease (cyst growth). The medication targets and slows down the cyst growth in the kidneys of mice with a certain gene problem. This condition is similar to the human disease ADPKD. ADPKD is…

Getting Older: The Cellular Link to Disease Aging is a complex and inevitable part of life. As we grow older, the cells inside our bodies don't work quite as well as they used to. This makes us more vulnerable to getting certain diseases. A protein called mTOR is a central player in this process. It…

New Drug for Longevity Gets Health Hackers Buzzing The drug rapamycin is taking the health world by storm, but it's an old drug with a new role. For the past 20 or so years, its job has been to stop the immune system from attacking transplanted organs. Now, it seems this special compound may have…

Exploring Longevity Medicine with Daniel Tawfik In the 96th episode of the Wise Athletes Podcast, hosted by Joe Lavelle and Dr. Glenn Winkle, the show dives into the world of longevity medicine with Daniel Tewfik. Tewfik is the co-founder of Healthspan, a telemedicine provider, also known as distance healthcare. The company specializes in treatments aimed…

How Rapamycin Protects from Indomethacin Damage Pain meds like ibuprofen can be great for aches and pains, but too much is harmful to health. NSAIDs can wreak havoc with your gut, causing stomach sores like ulcers in the small intestine. A study from Japan looked into not only why this happens but also how to…

Early Prostate Cancer Trial Has Promising Signs The purpose of this Phase I trial was to see if encapsulated rapamycin (eRapa) is safe for men with early signs of cancer. That involved closely monitoring patients at low or medium level risk. Dr. Phillip Kemp Bohan at Brooke Army Medical Center led the study. The primary…

The Next Alzheimer's Disease Trial Needs Rapamycin This thought-provoking study advocates for human rapamycin trials in Alzheimer's disease. Why this drug? Rapa is already known for its anti-aging properties, as demonstrated in multiple experiments. Alzheimer's is an age-related illness. The theory is that targeting the aging processes may help slow or even prevent AD and…